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For the longitudinal analysis, a linear mixed-effects model assessed the interaction between sport and time, revealing a significant decrease in cornu ammonis area 1 (CA1) volume in football ( n = 36) athletes without an in-study concussion compared to volleyball ( n = 23) athletes (volume difference per year = −35.22 mm 3 p = 0.005).
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A regression analysis performed within football athletes similarly demonstrated a smaller subiculum volume among those at increased concussion risk based on athlete position ( p = 0.001). At baseline, football ( n = 59) athletes demonstrated a smaller subiculum volume than volleyball ( n = 32) athletes (−67.77 mm 3 p = 0.012). Athletes underwent high-resolution structural magnetic resonance imaging, and automated segmentation provided hippocampal subfield volumes. A prospective cohort study was conducted over a 5-year period tracking 63 football and 34 volleyball male collegiate athletes. The aim of this study is to determine whether there are longitudinal changes in hippocampal subfield volume in collegiate football. The hippocampus is composed of several distinct subfields with possible differential susceptibility to injury. Collegiate football athletes are subject to repeated traumatic brain injuriesthat may cause brain injury.